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Filtered Search Results
Medchemexpress LLC Benzyl-PEG5-amine | 86770-77-6 | 98.0% | C17H29NO5 | 50 MG
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Benzyl-PEG5-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein. This mechanism leverages the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Peg-based protac linker
- Used in the synthesis of protacs
- Utilizes ubiquitin-proteasome system
- Selectively degrades target proteins
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eMolecules EMOLECULES INC
5000491904 7-BROMOISOQUINOLINE 25G
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Medchemexpress LLC Benzyl-PEG7-amine 5mg
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Benzyl-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
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Medchemexpress LLC Argatroban (monohydrate) | 141396-28-3 | 99.6% | 5 MG
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Argatroban (monohydrate) is a direct, selective thrombin inhibitor used for research purposes. It is effective in preventing thrombus formation and has been studied for its use in creating animal models for thrombolysis.
- Suitable for high-speed applications
- Available in solid form
- Used to inhibit thrombin activity in animals
- Has potential for preventing thrombus formation without aggravating bleeding
- Can enhance reperfusion with TPA in patients with AMI
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Medchemexpress LLC 8-Hydroxyquinoline (8-Quinolinol) | 148-24-3 | 100.0% | 500 MG
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8-Hydroxyquinoline (8-Quinolinol) | 148-24-3 | 100.0% | 500 MG
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eMolecules EMOLECULES INC
5000491802 4-CHLORO-3-NITROQUINOLINE 25G
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eMolecules EMOLECULES INC
5000491852 7-BROMOISOQUINOLINE 5G
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Medchemexpress LLC DOTMA | 104872-42-6 | 99.91% | 670.57 | 200 MG
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DOTMA is a cationic lipid used as a non-viral vector for gene therapy. It is a component of liposomes for encapsulating siRNA, microRNA, and oligonucleotides, and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. It has demonstrated good gene transfection effects both in vitro and in vivo.
- Cationic lipid
- Non-viral vector for gene therapy
- Component of liposomes for encapsulating siRNA, microRNA, and oligonucleotides
- Used for in vitro gene transfection
- Promotes effective interaction between liposomes and cell membranes
- Induces positive charge on liposomes
- Good gene transfection effects both in vitro and in vivo
- High intravenous transfection activity in CD-1 mouse
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eMolecules 3-Hydroxyquinoline-4-carbonitrile | 100517-53-1 | MFCD18415946 | 250mg
Apollo Scientific | 3-Hydroxyquinoline-4-carbonitrile | 250mg | 562447445 | OR42261 | | 100517-53-1 | MFCD18415946 | 170.171 | C10H6N2O
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Medchemexpress LLC Nitrendipine | 39562-70-4 | 99.7% | 200 MG
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Nitrendipine (BAY-E-5009) is an orally active dihydropyridine calcium channel blocker, an analog of Nifedipine. It has been shown to induce apoptosis and possess antihypertensive effects. This compound can block alcohol and morphine withdrawal symptoms, reduce right ventricular hypertrophy, and mitigate pulmonary vascular changes induced by intermittent hypoxia. Furthermore, Nitrendipine exhibits anticancer effects on neuroblastoma cells.
- Orally active dihydropyridine calcium channel blocker
- Induces apoptosis
- Provides antihypertensive effects
- Blocks alcohol and morphine withdrawal symptoms
- Reduces right ventricular hypertrophy
- Mitigates pulmonary vascular changes induced by intermittent hypoxia
- Exhibits anticancer effects on neuroblastoma
- Inhibits Cav1.2 current
- Prevents behavioral signs of ethanol withdrawal
- Attenuates lipid peroxidation in the lung
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Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | 99.9% | 1 ML
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Danofloxacin mesylate is a potent fluoroquinolone antibiotic primarily utilized as a veterinary drug. It exhibits broad-spectrum bactericidal activity by targeting bacterial DNA gyrase, an essential enzyme for bacterial replication. Furthermore, this compound functions as a substrate for ATP-dependent efflux transporters, including P-glycoprotein (P-gp) and Multidrug Resistance-associated Protein 2 (MRP2), which are involved in drug transport mechanisms within cells.
- Fluoroquinolone antibiotic for veterinary use
- Possesses broad-spectrum bactericidal activity
- Inhibits bacterial DNA gyrase
- Acts as a substrate for ATP-dependent efflux transporters
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Apexbio Technology LLC Rocilinostat (ACY-1215) 1316214-52-4 200mg
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Rocilinostat (ACY-1215 CAS 1316214-52-4) is a selective inhibitor of histone deacetylase 6 (HDAC6) HDAC6 enzymatically regulates various cellular processes including protein trafficking cell-cycle progression and cytoskeletal organization and its dysregulated activity is implicated in tumor progression and cancer metastasis Rocilinostat potently inhibits HDAC6 (IC50 5 nM) while showing minimal activity against other HDAC isoforms and sirtuins (IC50 1 M) Preclinical studies using multiple myeloma (MM) cell lines and xenograft mouse models demonstrated rocilinostat can enhance acetylation of -tubulin disrupt protein stability pathways and sensitize cancer cells to proteasome inhibitors such as bortezomib and carfilzomib resulting in increased apoptosis and reduction in tumor growth
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Medchemexpress LLC 8-Hydroxyquinoline (8-Quinolinol) | 148-24-3 | >99.9% | 5 G
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8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that functions as a fungicide. It exhibits a MIC range of 27.56-55.11 μM (4-8 μg/mL) against clinical isolates of *Neisseria gonorrhoeae*. This compound can bind to copper, forming complexes that facilitate copper transport into cells. Additionally, 8-Hydroxyquinoline leads to an increase in micronucleated polychromatic erythrocytes and can cause hair depigmentation in mice.
- Functions as a fungicide
- Exhibits a MIC range of 27.56-55.11 μM (4-8 μg/mL) against clinical isolates of Neisseria gonorrhoeae
- Binds to copper, forming complexes that facilitate copper transport into cells
- Can lead to an increase in micronucleated polychromatic erythrocytes
- May cause hair depigmentation in mice
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Medchemexpress LLC Hydroquinidine | 1435-55-8 | 99.97% | 5 G
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Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and demonstrates antiarrhythmic efficacy.
- Potent ion channel blocker
- Strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Antiarrhythmic efficacy
- For research use only
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Apexbio Technology LLC Hesperadin 422513-13-1 200mg
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Hesperadin is a small-molecule ATP-competitive inhibitor targeting Aurora B kinase a serine/threonine-protein kinase involved in mitotic regulation By occupying the ATP-binding pocket of Aurora B and adjacent hydrophobic regions Hesperadin suppresses kinase activity with an IC50 approximately 250 nM In mitotic cells Aurora B-mediated phosphorylation of histone H3 Ser-10 is inhibited by Hesperadin this phosphorylation event is widely utilized as a mitotic biomarker Furthermore experimental applications of Hesperadin include investigating cell-cycle dynamics chromosome alignment and spindle checkpoint mechanisms as evidenced by its ability to disrupt proper chromosome alignment and segregation at approximately 40 nM IC50
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